Honestly, I do think Reynolds has enough charisma to headline a film, but even from the marketing I can already see people comparing this to the wit of Ant-Man. Check out the synopsis:
Based upon Marvel Comics’ most unconventional anti-hero, DEADPOOL tells the origin story of former Special Forces operative turned mercenary Wade Wilson, who after being subjected to a rogue experiment that leaves him with accelerated healing powers, adopts the alter ego Deadpool. Armed with his new abilities and a dark, twisted sense of humor, Deadpool hunts down the man who nearly destroyed his life.
Watch the red band trailer (definitely not suitable for all audiences):
DEADPOOL, which also stars Gina Carano and Morena Baccarin, is in theaters February 12, 2016.